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Revista Cubana de Medicina General Integral

Print version ISSN 0864-2125

Abstract

CRUZ MARTINEZ, Georgina et al. Adverse events of antimeningococcal Cuban vaccine. Rev Cubana Med Gen Integr [online]. 2011, vol.27, n.2, pp.187-196. ISSN 0864-2125.

Introduction: in our country there is a surveillance exhaustive system offering statistical information on the severe, less severe and slight adverse events related to vaccines. This surveillance system is carried out by the Basic Health Staff; however, in many occasions, if these events have a poor defined and of less severity symptomatology they could remain without diagnosis and without research. Objective: using the design of retrospective and descriptive study, it was possible to analyze the 381 infants aged 3 and 5 months received the programmed VAMNGOC-BC® vaccine according the national scheme in 2006. The tool used for collection of information from medical records was the Epidemiological Survey of Adverse Events of Vaccination, established by the National Immunization Program. Results: from the 381 infants received vaccine that year, there were 17 with adverse events. The great percentage was after administration of the first dose (3,01 %). The more frequent local manifestations was pain in the injection site with 50,00 % after the first dose and induration (66,67 %) after the second one. The more frequent systemic adverse effects in the first dose were fiver (54,55 %) and irritability (27,27 %). The incidence of infants with adverse events was higher at the first 72 h (3,41 %) and in the first dose (2,46 %). However, most of manifestation disappeared during the first 72 h (3,41 by each 100 vaccinated infants, that is, that recovery was fast. Conclusions: the local and systemic adverse events were discrete with predominance of the second ones for both doses of vaccine and the fever was the more frequent event after applied the two doses. There was neither severe adverse event requiring admission nor sequelae.

Keywords : Adverse events; antimeningococcal vaccine; local adverse events; systemic events; epidemiological surveillance.

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