Introduction:

The prevalence of liver disease in pregnancy is not negligible, since such cases occur in 3 % to 5 % of all pregnancies. Among the multiple causes are physiological changes of pregnancy, preexisting liver disease, liver disease acquired during pregnancy, and pregnancy-related liver disease.

Objective:

To describe gestational hypertransaminasemia.

Clinical case:

A patient with 37.4 weeks of gestation, 34 years old, white skin color, with personal pathological history of hearing impairment, arterial hypertension, under treatment with methyldopa (3 tablets daily for 2 years), obesity, infertility and varicose veins in lower limbs was referred from her health area for debuting gestational diabetes 2 months ago; since the first month, she suffers from occasional epigastralgia and elevated transaminase levels. Treatment with methyldopa was discontinued; there was clinical improvement; she is now asymptomatic and analytical, according to normal transaminase levels.

Conclusions:

A fatal outcome for her and her fetus was avoided thanks to the timely diagnosis of toxic hypertransaminasemia (for the prolonged use of methyldopa) and with the change of hypotensive medical treatment, in addition to the multidisciplinary work of the different specialties involved in her clinical.

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