Resumo

SEDENO CRUZ, Ibis; ALEMANY GONZALEZ, Jaime; CAMACHO RUAIGIP, Fariel  e  GARCIA GONZALEZ, Frank. Study of the clinical efficiency of briomonidine vs. timolol in the treatment of open-angle primary glaucoma. Rev Cubana Oftalmol [online]. 2002, vol.15, n.1. ISSN 0864-2176.

36 patients with diagnosis of open-angle primary glaucoma (OAPG) without previous treatment were studied. They were indicated timolol 0.5 % (1 drop twice a day) and after that, previous lavage with hypotensor, brimonidine 0.2 %. The intraocular pressure (IOP) and the adverse reactions were evaluated on the initial visit and on the first week, the first month and the second month. The results showed a decrease of the mean IOP compared with the initial (without treatment) with both drugs during the 2 months of treatment. A mean IOP of 17.1 mm Hg was obtained with timolol and 16.1 mm Hg with brimonidine. It represents a reduction of 7.7 mm Hg and 6.9 mm Hg, respectively. The most frequent systemic adverse reactions with the administration of brimonidine were dry mouth and headache, whereas the local adverse reactions were ocular pruritus and ocular hyperemia. The intensity of these symptoms was from mild to moderate. The study demonstrated that brimonidine has an effectiveness similar to that of timolol as regards the reduction of intraocular pressure with a good tolerability.

Palavras-chave : GLAUCOMA; OPEN-ANGLE [drug therapy]; TREATMENT OUTCOME; TIMOLOL [therapeutic use]; TIMOLOL [adverse effects]; ADRENERGIC AGONISTS [adverse effects]; ADRENERGIC AGONISTS [therapeutic use]; INTRAOCULAR PRESSURE [drug therapy].

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