Revista Cubana de Oftalmología
versión On-line ISSN 1561-3070
GARCIA GONZALEZ, Frank; SEDENO CRUZ, Ibis; ALEMANY GONZALEZ, Jaime y PERALTA FERNANDEZ, Jorge Orlando. Combined therapy with timolol and dorzolamide vs timolol and pilocarpine used in primary open-angle glaucoma. Rev Cubana Oftalmol [online]. 2006, vol.19, n.1, pp. 0-0. ISSN 1561-3070.
The objective of this study was to evaluate the efficacy of combined therapy with timolol and dorzolamide compared to timolol and pilocarpine. Thirty eight patients with primary open-angle glaucoma were randomly treated with 0,5 % timolol and 2 % dorzolamide (n= 19) or 0,5 % timolol and 2 % pilocarpine (n= 19) so as to analyze intraocular pressure (IOP) declines, effectiveness of treatment for 4 weeks, and local and systemic adverse effects. The initial mean IOP in the group of patients treated with timolol and dorzolamide decreased from 22,84 ± 1,77 mm Hg to 18,24 ± 1,84 mm Hg after 4 weeks of treatment, p. 0,01 (reduction of 4,60 mm Hg 22,14 %). Initial mean IOP (without treatment) in the other group treated with timolol and pilocarpine was reduced from 23,06 ± 1,29 mm Hg to 19,07 ± 1,23 mm Hg after the fourth week of treatment, p. 0,01 (reduction of 3,95 mm Hg/17,31 %). No significant differences (p > 0,05) were found between both lines of treatment and were equally effective in lowering IOP. The quality of life of patients, who received dorzolamide as adjunctive treatment, was higher; pilocarpine dosing lowered and there were no side effects such as driving and reading restrictions or ocular pain. Five patients (26,31 %) and two patients (10,52 %) mentioned bitter taste in mouth and conjunctival irritation respectively in relation to dorzolamide. In the medium-term, intraocular pressure was reduced with the application of dorzolamide as well as Pilocarpine combined with timolol. Dorzolamide showed lower interference in the quality of life of patients than Pilocarpine
Palabras llave : Glaucoma; dorzolamide.