Abstract

DEBESA PADILLA, Aymé; STEWART LEMES, George  and  CASAS MORELL, Eloisa. Character of sensitivization in renal petransplantation blood transfused patients with HLA; B8 and DR3 allelomorphs. AMC [online]. 2006, vol.10, n.4, pp.46-54. ISSN 1025-0255.

A descriptive study was conducted from October to November 2005 at the Manuel Ascunce Domenech Provincial Hospital to assess the range of transfusions involved in the character of the sensitivization response in receptors whit A1, B8, DR3 allelomorphs and combinations. For the sample were enrolled 71 patients with IRCt with A1, B8, DR3, A1B8 or xDR3 (A1DR3, B8DR3) who had been wait-listed for the Cuban National Renal Transplant program. The current average sensitivization percentages for each group of allelomorphs and for intervals of 1-10, 11-20, and more than 20 transfusions were calculated. A current average sensitivization percent age of up to 10 % was considered to be responsive. Both extreme responses matched within the interval of 11-20 transfusions, that is, non responsive values were found in patients whit A1B8(6,1 %) and xDR3 (0,0 %) allelomorphs, whereas those patients withB8 or DR3 allelomorphs showed significantly higher responsive values ( 52,5 % and 56,9 % respectively) for a lesser amount of transfusions. Less responsive patients corresponded, fundamentally, to those with allelomorphic combinations A188 and xDR3, with 11 to 20 transfusions. Responsiveness is generally associated to B8 and DR3 allelomorphs when the transfusion rate is less than 10. These results are in framing a transfusion protocol for patients waitlisted for transplantation by HLA type.

Keywords : KIDNEY TRASPLANTATION; ALLELES; BLOOD COMPONENT TRANSFUSION.

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