Abstract

BUENO RODRIGUEZ, José Carlos; HERNANDEZ MOORE, Elizabeth; AGUILAR ATANAY, Dayamnelis  and  CASTRO GUEVARA, José Enrique. Ceftriaxone versus cefotaxime as prevention in acute appendicitis. AMC [online]. 2009, vol.13, n.1. ISSN 1025-0255.

Background: The perioperative prophylactic use of antimicrobial in non complicated acute appendicitis, leads the reduction of the infections of the surgical place. Better or equal results from the pharmacoeconomic point of view with the monotherapy use of the cephalosporin family are obtained. Objective: To determine the cost-effectiveness relationship between two cefalosporins used as prevention in appendicectomized sickpeople. Method: A descriptive retrospective study of all the sick persons treated according to the antimicrobial guide of prevention for acute appendicitis was carried out from January 2000 and December 2005, in the Pediatric Surgery Service at Dr. Eduardo Agramonte Piña Educational Provincial Pediatric Hospital of Camagüey city. For the economic comparative evaluation, the cost-effectiveness analysis technique was used. The cost-effectiveness mean analysis and the cost-effectiveness increasing analysis were found according to the established formulas. Results: In the study 245 children received prophylactic treatment with Ceftriaxone ($ 3006.15) and 364 with Cefotaxime ($ 4036. 76). The cost-effectiveness mean analysis was about 12,47 $ /% of avoided infection with the use of Ceftriaxone, while the use of Cefotaxime was about 11,37 $ /% of avoided infection. Conclusions: The compared cefalosporins showed similar cost-effectiveness relationship as prophylaxis in acute appendicitis.

Keywords : Ceftriaxone; cefotaxime; appendicitis; antibiotic profilaxia; analysis of cost-efficiency; pharmaceutical economy; cost.

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