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Revista Archivo Médico de Camagüey

On-line version ISSN 1025-0255

Abstract

MARTINEZ DOMINGUEZ, Maritza; REYES OLIVA, Roberto; GUERRERO JIMENEZ, Gustavo  and  ARREDONDO BRUCE, Alfredo. New physiologic concepts of the peptic acid disease. AMC [online]. 2010, vol.14, n.3. ISSN 1025-0255.

Background: peptic acid disorders are the result of different pathogenic mechanisms, taken place by a misbalance between the acid excessive secretion and/or the decrease of the mucosa defensive barrier. These are commonly diseases in daily medical practice due to their chronicity; it represents an important cost in sanitary attention. Development: The key elements in the success of controlling these diseases are the development of potent and safe drugs on the physiologic bases. The histamine-2 receptor antagonists revolutionized the treatment of peptic acid disorders due to their innocuousness and effectiveness. The proton pump inhibitors represent an additional therapeutic advance due to the most potent inhibition in the acid secretion. The obtained data of the clinical trials and the observational experience has confirmed the effectiveness and security of these agents in the treatment of peptic acid disease. Paradigms in their speed and action duration underline the necessity of new chemical variants that just with a single dose produces a reliable duration of the acid control, particularly at night. Conclusions: this assessment provides a knowledge valuation in course of the physiology of acid production, to be able to face peptic-acid diseases as much as the challenges in course and the future instructions in the treatment of diseases mediated by acid.

Keywords : HISTAMINE ANTAGONISTS; SEQUENCE ANALYSIS PROTEIN; PHYSIOLOGY; PEPTIS ULCER; QUALITY OF LIFE.

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