Revista Archivo Médico de Camagüey
versión ISSN 1025-0255
SANTANA TELLEZ, Tomás Noel; MONTEAGUDO CANTO, Alina; SEGURA PUJAL, Leandro y DEL AGUILA GRANDEZ, Angie Yohana. Regression of left ventricular hypertrophy with the use of captopril. AMC [online]. 2010, vol.14, n.6, pp. 1-12. ISSN 1025-0255.
Background: arterial hypertension is associate to structural changes of the cardiovascular apparatus that are used for adapting to the function in a high tension environment. Objective: to determine the effectiveness of captopril in the regression of left ventricular hypertrophy in hypertensive patients, attended in a specialized consultation of arterial hypertension at the Manuel Ascunce Domenech University Hospital from January to December 2008. Method: a quasi-experimental study in one hundred forty-nine patients was carried out. The sample was constituted by a hundred patients. Results: a prevalence of left ventricular hypertrophy in hypertensive patients between thirty-six and forty-five years was found, after the use of captopril brought about a decrease of 12,0% of patients with abnormal geometric pattern of left ventricle with four years of evolution of arterial hypertension, and patients with abnormal geometric pattern of left ventricle with arterial hypertension in stage one was twenty-six. After the use of this drug, twenty-six patients presented normal geometric pattern of left ventricle. Conclusions: captopril is effective in the treatment of left ventricular hypertrophy mainly in patients with hypertension in stage one, with less than four years of evolution.
Palabras llave : HYPERTROPHY; LEFT VENTRICULAR; CAPTROPIL [therapeutic use]; EPIDEMIOLOGY, EXPERIMENTAL; HIPERTENSION.