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Revista Archivo Médico de Camagüey

On-line version ISSN 1025-0255

Abstract

AVILA PEREZ, Yuney Roman et al. Intensive pharmacovigilance of adrenergic agonists used in the severe patient care. AMC [online]. 2012, vol.16, n.6, pp.1675-1692. ISSN 1025-0255.

Backghround: pharmacovigilance is a branch of Pharmacology of recent development. It arises by events triggered with the pharmacological explosion after the Second World War, which allowed great advances in the treatment of diseases which before lead to a rapid and inexorably death or a severe disability. Objective: to observe treatments administered with adrenergic agonists used in the severe patient. Methods: a prospective observational study was performed on patients who were treated with adrenergic agonists in the intermediate care unit at the Municipal Hospital Manuel "Piti" Fajardo, Florida, Camagüey; from January to July 2010. The sample was constituted by 71 patients. The study took into account sociodemographic and epidemiological variables, type and degree of severity, causation, mechanisms of production of drug adverse reactions, as well as their final outcome.Results: more than fifty percent of patients with suspicion of adverse drug reaction was obtained to predominance of those in which were detected manifestations such as tachycardia, pallor and hypertension between signs and symptoms, according to adrenergic agonist was observed (type A) effects in those who acquired a moderate degree of severity, classified as proven, where the greatest percent of the sample needed treatment to the resolution of symptoms. Conclusions: a significant percent of patients highlighted who received treatment with adrenergic agonists in which suspected drug adverse reactions was detected to predominance in women over 50 years old, tachycardia as the most frequent manifestation in those classified as (type A) effects, regarded as moderate severity of tested type, which needed treatment to achieve the resolution of symptoms, the greatest percent of the sample studied were recovered without after-effects.

Keywords : PHARMACOVIGILANCE; ADRENERGIC AGONISTS; DRUG TOXICITY; INTERMEDIATE CARE FACILITIES.

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