Abstract

ARDILA MEDINA, Carlos Martín; BEDOYA GARCIA, Jader  and  PATINO GIRALDO, Jorge Eliecer. Immunomodulatory anti-inflammatory effect of moxifloxacin as an adjunct in periodontal therapy. AMC [online]. 2016, vol.20, n.4, pp.444-451. ISSN 1025-0255.

Background: periodontitis is an infectious disease that occurs as a result of the interaction between microorganisms and some different reactions of the host to infection. The anti-inflammatory immunomodulatory function of antimicrobial drugs such as moxifloxacin can be a useful quality in the treatment of periodontitis. Objective: to review the scientific literature related to the immunomodulatory effect of moxifloxacin. Methods: a systematic review of research conducted in humans or human cells published in Medline-Pubmed, SciELO, LILACS and academic Google between 1996 and 2015 data was performed using the following terms in different combinations: moxifloxacin, immunomodulation, cytokines, interleukins and tumor necrosis factor. Case series, duplicate results due to combinations of search terms, missing data, letters to the editor and historical revisions, were excluded. Development: a total of nine studies showed decreased release of the interleukins 1β, 6, 8, while five studies showed inhibition. Similarly, three publications showed inhibition of tumor necrosis factor α and three arranged reduction of their release. Conclusions: moxifloxacin, besides its effectiveness against the main periodontopathogens, has a significant immunomodulatory effect in the inflammatory process of periodontitis to be taken into account in the clinical decision to treat this disease.

Keywords : PERIODONTITIS [therapy]; IMMUNOMODULATION; ANTI-INFECTIVE AGENTS; COMMUNICABLE DISEASES; REVIEW LITERATURE AS TOPIC.