Abstract

NODA, Amaury  ; RODRIGUEZ, Boris; VIDAL, Arturo    and  CADIZ, Armando  . Immune-pharmacological actions of Intravenous Immunoglobulins. Vaccimonitor [online]. 2001, vol.10, n.1, pp.8-12. ISSN 1025-028X.

We have come a long way in the understanding of the mechanisms of action occurring upon infusion of intravenous immunoglobulin since the days when crude Cohn fraction II of human plasma was administered intramuscularly to patients suffering from Brutton’s agammaglobulinemia, up to modern times. A distinction should be made between mechanisms of action at the level of the pathogen causing the disease and those at the level of a given disease caused by the reaction of the host against the pathogen. The suppresive effect of intravenous immunoglobulins on autoinmune responses opens novel therapeutic prospects and provides a new approach for understanding the basic mechanisms that explain pathological autoinmunity.

Keywords : Intravenous immunoglobulins; mechanisms of action; autoimmunity; inflammation; pharmacological effects.

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