On-line version ISSN 1025-0298
PADRON, Jorge A et al. Determination of the accumulated Fo during saturated steam sterilization cycles in a fermentor used for vaccine production. Vaccimonitor [online]. 2001, vol.10, n.2, pp. 1-6. ISSN 1025-0298.
Technical literature related to sterilization processes in industrial equipment was reviewed. The Fo concept was described and its application for evaluating the efficiency of the sterilization process in a fermentor. The temperature profile in different sections of the fermentor was studied during the sterilization cycles. After the application of some modifications, a reliable SAL was obtained in all sections of the fermentor.
Keywords : Sterilization process; validation; reactors.