Abstract

RODRIGUEZ, Yoandra et al. IgG immune response induced by vaccination with the trivalent (canicola,copenhageni, mozdok) leptospiral vaccine vax-SPIRAL in risk population. Vaccimonitor [online]. 2001, vol.10, n.3, pp.7-12. ISSN 1025-028X.

The humoral immune response induced by the trivalent (canicola, copenhageni, mozdok) leptospiral vaccine, vax- SPIRAL, was studied in two risk populations of San José de Las Lajas, Cuba. The levels of IgG antibodies were evaluated before and after vaccination by means of ELISA, using whole-cell antigens of serovars mentioned above for coating the microtiter plates. Two-fold increasing of the IgG concentration after vaccination was defined as response criterion. The vaccine induced a similar IgG response in both populations, between 63,77% and 70,04%. A high seroprevalence of IgG antibodies against the three serovars was observed. Significant statistical differences (p<0,05) were obtained between IgG levels before and after vaccination. These results are the first demonstration of the immunogenicity of vax-SPIRAL in people expose at risk and evidence that the response may be influenced, among other factors, by the previous contact with the micro-organism.

Keywords : Leptospira interrogans; Immunogenicity; Humoral immune response; IgG ELISA; vax-SPIRAL.

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