Abstract

FUENTES MORALES, Dasha; GONZALEZ PUMARINO, Ramiro R; GONZALEZ NAVARRO, Bárbara O  and  NEGRIN RODRIGUEZ, Natacha. Study of Solid Tumors developed by mice during the production of Monoclonal Antibodies. Vaccimonitor [online]. 2003, vol.12, n.3, pp.11-17. ISSN 1025-028X.

Mice are one of the most important elements in the production of ascitic fluid. Solid tumors can occur during this process. The objective of this work was to characterize such tumors, in order to predict their effect on production. The information used, was obtained from the study of 12 250 animals, both males and females, grouped into 12 production batches of CB-HEP.1, ior r3 and ior t1 hybridomas. The time of tumor emergence, the incidence by sex and hybridoma type, as well as their anatomopathological characteristics were determined. Tumors were evident starting on day 14th after the inoculation, affecting 3.4% of mice by the 20th day post-inoculation. There were significant differences (p<0.05) between sexes (4.4% males and 2.3% females). In addition, a higher solid tumor incidence (3.87%) was detected with the CB-HEP.1 hybridoma. The histological analysis showed a plasmatic cell dyscrasia.

Keywords : Mice; ascitis production; solid tumors.

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