Abstract

RAMIREZ, Juan Carlos et al. Study of immunogenicity in mice of the Cuban Vi Polysaccharide Typhoid vaccine, vax-Tyvi. Vaccimonitor [online]. 2006, vol.15, n.2, pp.1-4. ISSN 1025-028X.

Salmonella enterica serovar Typhi is a microorganism causing more than 16 millions of typhoid fever cases with about 600 000 deaths per year around the world. Typhoid fever vaccines based on S. Typhi Vi capsular polysaccharide have been well received between producers and customers. The present work deals with the immunogenicity study in mice of the Cuban polysaccharide typhoid fever vaccine vax-TyVi. The experimental design included a control group and one group receiving 0.05 mL of Cuban vaccine by intramuscular route. Blood samples were taken at days -3, 7, 14, 21, 28, 42, 56 and 84, and the titers of IgG antibodies against Vi polysaccharide were measured by ELISA. Data were analyzed by group and sex. Seroconversion rates ( ≥ 4 fold increase of anti-Vi antibody titers over pre-immunization levels) were calculated. The antibody response induced after vaccination showed enhanced IgG titers against Vi polysaccharide in the vaccinated group (100% of seroconversion rates) while the control group kept its initial titers (0% of respondents). IgG response was significantly higher in females than in males.

Keywords : Typhoid fever; vaccines; vax-TyVi; immunogenicity; preclinics.

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