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Vaccimonitor

versión impresa ISSN 1025-028Xversión On-line ISSN 1025-0298

Resumen

BU-COIFIU, Raisa et al. Clinical and neuroimmunological aspects of meningoencephalitis by Streptococcus pneumoniae. Vaccimonitor [online]. 2007, vol.16, n.3, pp.7-12. ISSN 1025-028X.

After successful vaccination campaigns against Neisseria meningitidis and Haemophilus influenzae, there was an increase of cases of meningoencephalitis by Streptococcus pneumoniae. With the aim to describe the clinical characteristics, laboratory findings and complications found in a group of patients suffering from this disease between 1993 and 2006, to evaluate the state of the barrier blood-cephalo rachideous liquid (LCR) and the response pattern of intratecal synthesis of immunogobulins through reibergram, 12 children with meningo-encephalitis by Streptococcus pneumoniae who were hospitalized in the Pediatric Hospital of San Miguel del Padrón, Havana City, were studied. Albumin, IgA, IgM and IgG and their subclasses were dossified by radial immuno-diffusion in serum and cephalo-rachideous liquid. The most frequent age was that lower than one year. The greater complications were: septic and brain edema. There were three deceased patients. Patterns of the three greater classes of immunoglobulins appeared in 33% from the total. The two patterns of subclasses of IgG more IgM had in common the dysfunction of the barrier blood-cephalorachideous liquid. The intratecal immune response in patients with meningo-encephalitis by Streptococcus pneumoniae has distinctive characteristics differentiating it from other meningoencephalitis of bacterial origin; so as a whole they could be elements to be taken into account to help the doctor in its differential diagnosing and in the tactic to develop a Cuban vaccine.

Palabras clave : Meningoencephalitis; Streptococcus; immunoglobulins; synthesis pattern.

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