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Vaccimonitor
versión On-line ISSN 1025-0298
Resumen
MARTINEZ, Clara E et al. Toxicity by repeated dose of magnetically treated CM-95 Solution in Sprague Dawley rats. Vaccimonitor [online]. 2008, vol.17, n.2, pp. 25-34. ISSN 1025-0298.
In this study the toxicological evaluation at repeated dose by the method of limit test of the candidate to magnetically treated immunopotentiator CM-95 Solution was carried out; according with regulations of the Organization for Economic Cooperation and Development included in guide 407. The objective was to establish the possible organic and functional lesions caused by the magnetically treated CM-95 Solution with maximum permissible magnetic induction (0,16 T), for obtaining the candidate to immunopotentiator. Three groups were used: Experimental, Control and Satellite. As experimental Biomodels, male and female Sprague Dawley rats were used, with 150 to 200 g weights. During the study neither clinical signs of toxicity nor deaths in any of the animals of the treated groups were registered. There was not affectation of the corporal weight during the test. There was not change of the corporal weight during the trial. Although there were variations of some haematology and biochemical parameters, they had no biological significance. Macroscopic or microscopic lesions were not found; just proliferation effects were observed, in the lymphoid tissues of the thymus and spleen, related to the response of immune system. Magnetically treated CM-95 Solution, showed no toxicity in the animal model and dose level used, and under the observed experimental conditions.
Palabras clave : Toxicology; repeated dose; magnetically treated CM-95 Solution; Sprague Dawley rats.