Abstract

CASTRO, Raúl Lázaro et al. Sensitivity and Specificity of Skin Prick Test with standardized allergen extracts of Dermatophagoides pteronyssinus in adults . Vaccimonitor [online]. 2013, vol.22, n.2, pp.24-29. ISSN 1025-028X.

Skin Prick Test (SPT) using standardized mite allergen extracts is a sensitive and reliable diagnostic tool. IgE sensitization to domestic mites has been identified worldwide as a major cause of respiratory allergic diseases. In Cuba, the most relevant species are: Dermatophagoides pteronyssinus (Dp), D. siboney and Blomia tropicalis. The aim of this work was to determine the diagnostic efficacy of SPT, using an standardized allergen extract of Dp, of national production (VALERGEN-DP, BIOCEN) and two other well known foreign commercial products (A: ALK, Netherlands and B: Stallergenes, France). An analytical study involving 50 patients with allergic antecedents to domestic dust and positive serum IgE and 50 with identical antecedents, but negative serum IgE was conducted. Replicate punctures were performed in both arms of patients using a concentration of 20 000 BU/mL. SPT with VALERGEN-DP produced a wheal mean of 43.5 mm², superior value statistically significant with respect to A product (p = 0.002). Diagnostic coincidence among the three products was 98-99 %. SPT with VALERGEN-DP showed 98% of specificity and 82% of sensibility and significant differences were not detected (p>0.05) between products for these parameters. Diagnostic efficacy of SPT using a validated allergenic extract of national production (VALERGEN-DP) was similar to SPT with the other standard extracts, what supports its use for the diagnosis from the sensitization to Dermatophagoides pteronyssinus in patients with allergic symptoms to domestic dust.

Keywords : skin prick test; Dermatophagoides pteronyssinus; allergy.

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