SciELO - Scientific Electronic Library Online

 
vol.25 número3Incremento en la capacidad de procesamiento para la producción de N-Glicolil GM3Determinación de las competencias organizacionales y de procesos en un centro del sector biofarmacéutico índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Vaccimonitor

versão impressa ISSN 1025-028Xversão On-line ISSN 1025-0298

Resumo

CUBA-ROMERO, Yaritza; GAINZA-SANTOS, Noemi; SALTAREN-COBAS, Alfredo  e  NARANJO-MEDINA, Mariela. Evaluation of immunogenicity and protective homologous capacity of a tetravalent Leptospira vaccine candidate, for veterinary use, including serogroup Ballum. Vaccimonitor [online]. 2016, vol.25, n.3. ISSN 1025-028X.

Immunogenicity is an important parameter for studies of immunogens. The humoral immune response against leptospirosis is vital for resistance to the infection; hence this paper is proposed to evaluate the immunogenicity and protective homologous capacity of a tetravalent candidate that includes serogroup Ballum in its formulation. The strain 245-12 classified as L. borgpetersenii serovar Ballum was used in this paper, isolated from a confirmed case of leptospirosis. Five (5) batches of a tetravalent vaccine preparation were formulated with this strain previously characterized from the point of view of its virulence, which also contains the strains Canicola, Icterohaemorrhagiae and Pomona contained in the Polyvalent-Leptospira vaccine for veterinary use. The immunogenicity of this preparation was assessed by micro agglutination and homologous protection capacity in Golden Syrian Hamster before the challenge with 100 LD50. Animals were immunized with two doses of vaccine (0.1 mL) with an interval of 15 days; the challenge was carried out 14 days after the immunization schedule was ended. The results were compared with those obtained with the Polyvalent-Leptospira vaccine. All the batches of the tetravalent preparation formulated complied satisfactorily with the quality controls. The batches formulated in this study showed a significant immunogenicity and homologous protection capacity against serogroup Ballum and they were able to eliminate the carrier state in the immunized animals. This paper, for the first time sets the bases for novel vaccine formulations, in animals, containing the serogroup Ballum.

Palavras-chave : Leptospira; vaccines; immunogenicity; Ballum.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons