Abstract

BARRIOS-LAMOTH, Eneida; DORTA-CONTRERAS, Alberto Juan; MARTINEZ-LARRARTE, José Pedro  and  LASTRE-GONZALEZ, Miriam. Intrathecal synthesis of IgG against herpes virus as neuroimmunological evidence in pediatric patients. Vaccimonitor [online]. 2019, vol.28, n.3, pp.91-96.  Epub Dec 01, 2019. ISSN 1025-028X.

In a neuroinflammatory process a polyclonal and poly-specific activation is produced in cerebrospinal fluid. This activation starts from the first days and may persist for a long time. The clones not related directly against the biological agent do not proliferate by apoptosis. Reibergram determine if part of the immunoglobulins content in cerebrospinal fluid belongs from the blood or it is synthesized in the central nervous system. Antibody index determines if the specific antibodies was synthesized intrathecally. By these tools it can be possible to identify the humoral immune response against some herpes virus in pediatric patients suffering from a central nervous system inflammatory process. Quantification of specific IgG against citomegalovirus, varicella zoster and herpes simplex virus in serum and cerebrospinal fluid was done by ELISA. Specific Antibody index against these viruses were similar for the different age groups, which confirm the early exposure of the population.

Keywords : cerebrospinal fluid; herpes simplex virus; varicella zoster virus; cytomegalovirus.

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