Abstract

DE LA NUEZ VEULENS, Ania  and  RODRIGUEZ, Rolando. G Protein-coupled receptors as targets for drug design. Biotecnol Apl [online]. 2009, vol.26, n.1, pp.24-33. ISSN 1027-2852.

G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many of the basic processes in the body, and because they are present in all tissues. Unfortunately, a structure-based rational design is very difficult for GPCRs; the structures available for modeling purposes are only for family A. Despite this fact, research has continued and progressed, using combined structure-based techniques. This review intends to summarize this work.

Keywords : GPCR; 7TM; receptor; virtual screening; docking; molecular modeling; drug design.

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