SciELO - Scientific Electronic Library Online

 
vol.26 issue4Influence of albumin content and freeze-drying on the immunogenicity of human recombinant Interferon alpha-2b in miceAnhydrobiotic cells of the nematocidic agent Tsukamurella paurometabola C-924 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Biotecnología Aplicada

On-line version ISSN 1027-2852

Abstract

LAZO, Laura et al. Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III. Biotecnol Apl [online]. 2009, vol.26, n.4, pp.333-337. ISSN 1027-2852.

In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.

Keywords : Dengue; vaccine; P64k; carrier.

        · abstract in Spanish     · text in English     · English ( pdf )