SciELO - Scientific Electronic Library Online

vol.28 issue1Using reibergrams to evaluate the intrathecal synthesis of C3c and C4 in children affected with Neisseria meningitidis meningoencephalitisComparison of three methods for DNA extraction from paraffin-embedded tissues author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Biotecnología Aplicada

On-line version ISSN 1027-2852


HERNANDEZ, Julio C et al. Diagnostic value of alpha-fetoprotein for hepatocellular carcinoma. Biotecnol Apl [online]. 2011, vol.28, n.1, pp.34-39. ISSN 1027-2852.

Hepatocellular carcinoma (HCC) variously occupies the fifth or sixth position as the most frequent neoplasia worldwide. The present work used alpha-fetoprotein (AFP) determinations on the ultra-micro analytical system (SUMA®) as a tumoral marker in 189 cirrhotic patients evaluated at the Center for Medical and Surgical Research between January 1999 and September 2005. The principal factors associated to increases in AFP were HCC and viral cirrhosis. In all, 22 patients (11.64%) suffered from HCC, with viral cirrhosis caused mainly by hepatitis C virus infections as the most important etiological factor. AFP as a tumoral marker displayed a sensitivity of 68.18% and a specificity of 92.17%, which increased to 86.36 and 100% respectively when combined with abdominal sonography. It is concluded that AFP is valuable for the diagnosis of HCC.

Keywords : hepatocelular carcinoma; cirrhosis; alpha-fetoprotein.

        · abstract in Spanish     · text in English     · English ( pdf )