Abstract

SAUREZ-MARTINEZ, Giselle  and  BENCOMO-YANES, Anamary. Nimotuzumab, effective immunotherapy for the treatment of malignant epithelial tumors. Biotecnol Apl [online]. 2014, vol.31, n.2, pp.159-167. ISSN 1027-2852.

Nimotuzumab, a humanized monoclonal antibody, is a novel drug against the epidermal growth factor receptor, which is a protein that is highly expressed in malignant tumors of epithelial origin. This paper presents its physicochemical and pharmaceutical characteristics, the results of pre-clinical and clinical research, and the international regulations for the diseases for which its use has been indicated: in advanced head and neck tumors, malignant brain tumors in adults and children, and advanced esophagus tumors. Its safety profile, efficacy and effectiveness studied before and after its regulatory approval are also described. Finally, recommendations are given for its dosage according to clinical evidence, for the appropriate therapeutic use of this medication.

Keywords : epidermal growth factor receptor; nimotuzumab; cancer treatment; targeted therapy; biological therapy.

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