Resumo

VIZOSO PARRA, Angel; GARCIA LOPEZ, Arilia  e  RAMOS RUIZ, Alberto. Ausencia de potencial genotóxico in vitro e in vivo de un extracto fluido de PIPER AURITUM H.K.B.. Rev Cubana Plant Med [online]. 1999, vol.4, n.2, pp.57-64. ISSN 1028-4796.

We present results obtained in evaluation of genotoxic potential of a fluid extract, using ethanolic menstrum to 70 % from Piper auritumH.K.B. (caisimón de anís) in three short term trial systems, two in vitro, using Ames trial, and D-30 Aspergillus nidulans system (somatic segregation trial), and other in vitro, using micronuclei induction test in mouse bone marrow. In Ames trial, we evaluated concentrations in a rank of 50 to 5 000 µg/plate to strains TA-1535, TA-100, and TA-98 as well as to strain TA-1537 of 500 to 5 000 µg/plate. In somatic segregation trial, concentrations of 0,06 to 1,80 mg of total solids /mL, were analyzed. For micronuclei induction, a doserank of 283,00 to 1 134,63 mg/kg of body weight (B.W.) was assayed. Results obtained showed that fluid extract from Piper auritum H.K.B., was moderately cytotoxic in D-30 Aspergillus nidulans system, but not in Ames trial, and in micronuclei test. There wasn't genotoxic response in all three systems used.

Palavras-chave : PLANTS, MEDICINAL; MICRONUCLEI TESTS; CLINICAL TRIALS; ASPERGILLUS NIDULANS; BONE MARROW [drug effects]; MICE.

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