Resumo

CESPEDES VALCARCEL, Alfredo; CORRAL SALVADO, Aida; DIAZ OLIVERA, Clara  e  MORALES FUNDORA, Yanet. Efecto del nerium oleander l: En modelo de corazón aislado de cobayo. Rev Cubana Plant Med [online]. 1999, vol.4, n.2, pp.74-78. ISSN 1028-4796.

Authors performed a pharmacological and pharmacognosical study of Nerium oleander L. to assess presence of active metabolites in the plant, and in a guinea pig isolated heart (langerdoff) and to corroborate its cardiotonic effect. We found presence of cardiotonic glycosides. There was an increase P < 0.05) cardiac muscle contractility using fluid extract with hydroalcoholic menstrum (30 %) in doses of 0,71 mg/g and 1,39 mg/g of heart weight. However, dose of 5,13 mg/g provoked arrthytmias. Coronary flux was unchangeable.

Palavras-chave : OLEANDER [pharmacology]; HEART [drug effects]; GLYCOSIDES; GUINEA PIGS.

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