Resumo

VIZOSO PARRA, Ángel et al. Evaluación del efecto genotóxico en extractos fluidos de Plantago lanceolata L. (llantén menor) y matricaria recutita L. (manzanilla). Rev Cubana Plant Med [online]. 2000, vol.5, n.2, pp.59-63. ISSN 1028-4796.

Potential genotoxic action of fluid extracts of Plantago lanceolata L. (Llantén menor), and Matricaria recutita L. (Chamomille) was assessed by 2 genotoxic trials: mitotic spreading in D-30 Aspergillus nidulans and micronuclei induction in bone marrow of the mouse. In mitotic spreading trial, fluid extracts of Plantago lanceolata L. and Chamomille, with 5 and 6 concentrations in a range of 0,6-4,76, and 0,016-0,652 mg of total solids/mL, respectively, were assessed. In micronuclei induction trial, for Plantago lanceolata L., dose of 1875; 3,750, and 6,000 g/kg of body weight (bw), and in the case of Chamomille, dose of 1,23; 1,96, and 2,45 g/kg of bw),were tested. In none of trials performed, it was possible to detect occurrence of cytotoxic and genotoxic effects.

Palavras-chave : PLANTAGO; ASPERGILLUS NIDULANS; BONE MARROW; MUTAGENICITY TESTS; MICRONUCLEUS TESTS; MICE.

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