Resumo

PILOTO FERRER, Janet; RAMOS RUIZ, Alberto; VIZOSO PARRA, Ángel  e  GARCIA LOPEZ, Arilia. Evaluación del potencial genotóxico de un extracto fluido de incienso (artemisia Absinthium L.). Rev Cubana Plant Med [online]. 2000, vol.5, n.2, pp.64-67. ISSN 1028-4796.

We assessed mytagenic activity of a fluid extract from Artemisia absinthium L. (incense) prepared with an 70 % ethanol menstrum. Two test were used: Ames´ test and micronuclei induction test in bone marrow of the mouse. In the former one, results were negatives in all strains of Salmonella typhimurium tested: TA 1535, TA 1537, TA 98, and TA 100, using a plateincorporation protocol and concentrations up to 5 mg/plate. In micronuclei trial, two oral administration were made at a rate of 10 mL/kg 24 hours apart, sacrifice was performed 24 hours after the last application. Doses were of 500, 1 000, and 2 000 mg/kg. There weren´t variations in relationship between polychromatic erythrocytes (PCE), and the normochromatic ones (NCE), indicator of medullary toxicity. Neither we found significant alterations in micronucleated PCE frequency amongst different groups of treatment.

Palavras-chave : ARTEMISIA; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM; BONE MARROW; MICE.

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