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Revista Cubana de Plantas Medicinales
versión On-line ISSN 1028-4796
Resumen
VIZOSO PARRA, Ángel et al. Evaluación mutagénica de un extracto fluido con un menstruo etanólico al 70 % de teloxys ambrosioides.weber (apasote). Rev Cubana Plant Med [online]. 2000, vol.5, n.3, pp.102-107. ISSN 1028-4796.
The results obtained on evaluating the mutagenic potential of a fluid extract with an ethanol menstruum 70 % of Teloxys ambrosioides L. Weber (wormseed) in 2 systems of short-term tests, in vitro Salmonella/microsome system (Ames) and the in vivo system using the micronucleus induction test in mouse bone marrow, are presented. In the Ames? test, it was observed a positive response with the strains of Salmonella typhimurium with and without metabolic activation within the range of studied concentrations. Doses of 500, 1000 and 2 000 mg/kg of body weight were used in the micronucleus induction test. The results showed that the extract of Teloxys ambrosioides L. Weber was mutagenic in the Salmonella/microsome system. No genotoxic response was found among the doses studied in the in vivo assay.
Palabras clave : PLANTS, MEDICINAL [genetic]; PLANTS, MEDICINAL [toxicity]; PLANT EXTRACTS [toxicity]; IN VITRO; SALMONELLA TYPHIMURIUM; ANIMALS, LABORATORY; MICE; MEDICINE, HERBAL.