Resumen

CASTELLANOS PUERTO, Edelis; RODRIGUEZ ACOSTA, My Mireida; VAZQUEZ GONZALEZ, Tatiana  y  SIN MAYOR, Adriana. Efecto antiviral del extracto acuoso de Aloe barbadensis contra el virus de la hepatitis B. Rev Cubana Plant Med [online]. 2001, vol.6, n.1, pp. 7-11. ISSN 1028-4796.

An in vitro and in vivo experiment was made by using hepatitis B wild virus and transgenic balb/c mice in order to assess the antiviral action of Aloe barbadensis Miller (sábila). We used concentrations of Aloe b. M of 0,1; 0,2; and 0,3 mg/mL against a fixed concentration of the hepatitis B virus antigen standard of 83,75 Ng/mL during 24, 48, 72 hours; 7, 14 and 21 days. Antigen quantifications were carried out by sandwich-type enzime-linked immunosorbent assay (ELISA). As the best antiviral activity was achieved at 21 days, using a 0,3 mg/mL concentration, it was given to the transgenic mice group. A decrease of the virus antigenic expression was obtained compared with the group of transgenic mice that was treated with bi-distilled water.

Palabras clave : PLANT EXTRACTS [therapeutic use]; MEDICINE, HERBAL; PLANTS, MEDICINAL; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B [drug therapy]; ENZIME-LINKED IMMUNOSORBENT ASSAY; ANTIVIRAL AGENTS [therapeutic use]; ALOE [therapeutic use]; MICE, TRANSGENIC.

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