Resumen

TILLAN CAPO, Juana; RIBAS AVILA, María del Carmen; CASTRO MENDEZ, Irma  y  CARRILLO DOMINGUEZ, Carmen. Actividad antiinflamatoria de extractos de derivados de la caña de azúcar. Rev Cubana Plant Med [online]. 2002, vol.7, n.2. ISSN 1028-4796.

Wistar rats were used in the acute edema of the paw induced by subplantar injection of 0.1 mL of carrageen to evaluate the antiinflammatory activity of dry ethanol extract from sugar cane wax (SCEE) 500 and 1000 mg/kg, ethanol extract from sugar cane wax obtained in the proportion 1:5 (SCEE5) and 1:10 (SCEE10) fresh sample, 200 mg/kg, ethanol extract obtained from cachaza (CHEE) 500 and 1 000 mg/kg, raw wax (RW) 200 mg/kg, and cachaza oil without solvent (CHO) 2.5 and 5.0 mL/kg. The solid substances were prepared at 20 % in propylenglycol and the intraperitoneal administration was used in all cases 30 min before the edema induction. It was observed that dry wax and the dry and fresh ethanol extracts produced a significant reduction of the edema of the rat's paw induced by carrageen. As regards cachaza, only the ethanol extract and the oil assayed at doses of 500 mg/kg and 2.5 mL/kg of body weight, respectively, did not show any marked reduction of edema. It was concluded that the antiinflamatory susbstances are mostly found in wax and that the ratio wax:ethanol 1:5 may be used to obtain them.

Palabras clave : ANTIINFLAMATORY AGENTS [therapeutic use]; PLANTS MEDICINAL; PLANT, EXTRACTS [therapeutic use]; EDEMA [drug therapy]; RATS, WISTAR; SUGAR ALCOHOLS; DISEASE MODELS, ANIMAL.