Resumo

GARCIA-GONZALEZ, Mildred; COTO-MORALES, Teresita; GONZALEZ-CAMACHO, Sara  e  PAZOS, Liliana. Toxicidad subcrónica del extracto acuoso de las hojas y los brotes florales de Stachytarpheta jamaicensis (L.) Vahl. (Verbenaceae). Rev Cubana Plant Med [online]. 2002, vol.7, n.2. ISSN 1028-4796.

The toxicity of the leaves and floral buds of the botanical medicinal species Stachytarpheta Jamaicensis (L.) Vahl was determined The botanical material (leaves and floral buds) was collected in February, 1996, by Mr. Victor Rojas from the National Biodiversity Institute (witness number 400 VR), in Santa Rosa, Guanacaste, in the following coordinates:10°50´20´´N-85°37´30´´W and an altitude of 290 msnm. The aqueous extracts prepared by decoction of the leaves and floral buds of Stachytarpheta jamaicensis were orally administered to NGP male and female rats. The extract from the leaves was administered for 90 days and that of floral buds during 60 days. Both extracts were given during 5 consecutive days per week. The control groups received 0.5 mL of distilled water per animal The aqueous extract from leaves caused 40 % of mortality both, in males and females. Signs of toxicity were evidenced with the administration of extract from floral buds, with no mortality. All the registered signs suggest a general depressing effect on the central nervous system. That's why it is stated the need of making biological tests to validate the possible sedative-tranquilizing effect of this plant and the design of dose-effect curves of the toxicity of this plant.

Palavras-chave : PLANTS, MEDICINAL [toxicity]; PLANT EXTRACTS [pharmacology]; PLANT EXTRACTS [toxicity].