Resumen

SANCHEZ, Nora; BU, Margarita; NIURKA LEON, Lic.  y  PEREZ-SAAD, Héctor. Efecto de la Spirulina platensis en la toxicidad producida por acrilamida. Rev Cubana Plant Med [online]. 2003, vol.8, n.1. ISSN 1028-4796.

Spirulina platensis is a green-blue microalga with a high nutritional value and with pharmacological properties of interest. 2 experiments were made. In one of them the lethality of DL10, DL50 and DL90 of acrylamide in mice was determined. To this end, 1000 mg/kg of Spirulina were administered by oral route 1 hour or 5 days before the administration of acrylamide. In the other experiment, Spirulina was administered at doses of 500 mg/kg daily by oral route during 3 weeks previous to the administration of 100 mg/kg of acrylamide by intraperitoneal route during 5 days. Litchfield and Wilcoxon's methods as well as Fischer's Exact Probability were used with a p< 0,05. In no case Spirulina prevented the mortality produced by acrylamide even when it was well used at unique doses or repeatedly for a short period of time. The previous result discarded an antagonism of pathological character and gave the possibility to study the influence of this microalga on axonal neuropathy induced by the prolonged administration of acrylamide.

Palabras clave : ALGAE; ACRYLAMIDE [toxicity]; MICE.