Resumen

VEGA MONTALVO, Raiza et al. Toxicidad aguda oral de la droga seca de Epilobium parviflorum L. Rev Cubana Plant Med [online]. 2003, vol.8, n.2. ISSN 1028-4796.

The acute toxicity of a dry drug obtained from Epilobium parvioflorum L. recommended for its administration in the form of decoction was determined. The drug was orally administered to Wistar rats (150-200 g) by the limited dose trial at 2000 mg/kg. The animals were under observation during 14 days and at the end of this period they were sacrificed to perform the autopsy. A macroscopic examination of organs and tissues was made as well as an histological analysis of heart, kidney, lung, liver, spleen, brain and genitalia. The relative weight of ovaries, testicles, seminal vesicle and prostate was also determined. As a result, it was observed that the substance did not present either important toxicity or mortality. The alterations found in the histological analysis of the organs were attributed to artifacts originated in the sacrifice of animals. The statistical processing of the relative weight of the analyzed organs did not show significant differences as regards the control group. It was concluded that the dry drug of Epilobium parviflorum L, is not toxic, according to the established classification criterion.

Palabras clave : PLANTS, MEDICINAL; PROSTATIC DISEASES; ANTI-INFLAMM ATORY AGENTS; RATS, WISTAR; MICE.