Revista Cubana de Plantas Medicinales
versão On-line ISSN 1028-4796
BUZNEGO RODRIGUEZ, María Teresa et al. Effects of aqueous, ethanol, chloroform and toluene extracts of Brunfelsia nitida Benth on the animal´s exploring behavior and analgesia tests. Rev Cubana Plant Med [online]. 2005, vol.10, n.2, pp. 0-0. ISSN 1028-4796.
The neuropharmacological effect of aqueous, ethanol, chloroform and toluene fractions from Brunfelsia nitida Benth dry leaves, through acute administration, on animal's exploring behavior and analgesia test models was assessed. The aqueous fraction had a sedative effect on animal's exploring behavior at doses of 100 and 500 mg/kg and significantly reduced dose-dependent response to pain in acetic acid-induced test, without changes in the reaction time of the hot-plate method. The ethanol fraction brought about a significant reduction of the animal's exploring behavior at a dose of 200 mg/kg without affecting latency and length of stay in the 10-cm central circle as well as a decrease in acetic acid-induced contortions at doses of 40 and 200 mg/kg and in the reaction time of the hot-plate method. The chloroform fraction had a sedative effect on the animal's exploring behavior at doses of 40 and 200 mg/kg without changing latency and length of stay in the 10-cm diameter. central circle. These doses significantly reduced acetic acid-induced response to pain without modifying the reaction time. The toluene fraction did not change any of the used models. No parallelism was observed between the dose-effect curves of the animal´s exploring behavior and the analgesia test of each fraction; therefore, the results indicate that there is no molecular relation between both pharmacological effects. In conclusion, the sedative and analgesic effects seem to be caused by different active principles.
Palavras-chave : Brunfelsia nitida Benth; exploring behavior; analgesia.