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Revista Cubana de Plantas Medicinales

versión On-line ISSN 1028-4796

Resumen

TILLAN CAPO, Juana; GOMEZ MIRABAL, Juan Miguel  y  MENENDEZ CASTILLO, Rosa. Lowering lipid effect of Aloe vera L. Rev Cubana Plant Med [online]. 2005, vol.10, n.3-4. ISSN 1028-4796.

The lowering lipid activity of the aqueous extract and of the gel of Aloe vera L., both freeze dried, was evaluated on albine mice in an acute model of hyperlipidemia induced with triton. The animals were intraperitoneally administered 500 mg/kg of Aloe vera L. aqueous extract or gel, according to the treatment, together with 200 mg/kg of triton. A control group with sodium chloride solution 0.9 % and a control group of the model administered with triton were included. 18 hours later, the concentrations of total cholesterol and its fractions of high and low density and triglycerides were determined in serum. Significant reductions ( p <0.01) of the concentrations of total cholesterol, triglycerides and LDL-cholesterol were found in the serum of animals treated with gel, as well as with the aqueous extract in relation to the concentrations obtained in the group of animals treated with triton only. It may be concluded that the Aloe vera L. extract and its gel revealed a lowering lipid effect at the assayed dose in the model of hyperlipidemia induction (triton), probably by interruption of the feedback mechanisms inhibiting the endogenous lipidic synthesis.

Palabras clave : Aloe vera L; gel,; triton,; lowering lipid effect; cholesterol; triglycerides.

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