SciELO - Scientific Electronic Library Online

 
vol.11 número1Tamizaje fitoquímico, actividad antiinflamatoria y toxicidad aguda de extractos de hojas de Annona squamosa L.Evaluación del potencial genotóxico de Boerhavia erecta L. índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Plantas Medicinales

versión On-line ISSN 1028-4796

Resumen

BLANCO HERNANDEZ, Neylim; RAMOS RUIZ, Alberto  y  VIZOSO PARRA, Ángel. Toxic and genotoxic evaluation of the fluid extract from Ocimum gratissimum L. . Rev Cubana Plant Med [online]. 2006, vol.11, n.1. ISSN 1028-4796.

The acute toxicity and the genotoxic activity of the fluid extract of leaves of Ocimum gratissisum L. were evaluated by two short-term assay systems, one in vitro with the strain D-30 from Aspergillus nidulans, and another in vivo, the micronucleus test in mouse bone marrow. The acute toxicity of the extract was proved by the mortality observed that rose to 50 % in the 3g/kg dose, which was dose dependant. It was found a little accentuated genotoxic response of the fluid extract of O. gratissimum 30 %. The results allowed to conclude that this extract showed acute toxic effects and histologic signs of hepatotoxicity and nephrotoxicity. It was not genotoxic neither for the strain D-30 from Aspergillus nidulans in the mitotic segregation test, nor in the micronucleus test in mouse bone marrow.

Palabras clave : Ocimum gratissimum L; Aspergillus nidulans ; micronuclei test; acute toxicity; genotoxicity.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons