Resumo

BERTGES, Luiz Carlos et al. Effect of Calendula officinalis infusion on indomethacin-induced gastric lesions in Wistar rats. Rev Cubana Plant Med [online]. 2006, vol.11, n.2, pp. 0-0. ISSN 1028-4796.

Calendula officinalis is a phytopharmaceutical believed to inhibit gastric emptying and to have hypoglycemic and gastroprotective effects. We aimed to study the putative effect of an infusion of Calendula officinalis on indomethacin-induced gastric lesions. 30 adult male Wistar rats, divided in 2 groups, received indomethacin 20 mg/kg through gavage. Group A (Study) further received 1 mL of 10 % doses of Calendula officinalis, and group B (Control) received saline, for 2 days. After this period, the stomachs were extracted and examined for lymphocytic and neutrophylic infiltrates, and for mucosal lesions such as ulcers and erosions. We concluded that Calendula officinalis did not significantly influence the appearance of such alterations in the indomethacin-injured gastric mucosa.

Palavras-chave : Calendula officinalis; indomethacin; gastric injury; rats.