Resumen

CARMONA FERNANDEZ, Rolando; LOPEZ, Orestes Darío; GONZALES SANABIA, María Lidia  y  MUNOZ CERNADA, Adriana. Optimization of a process of obtention of aqueous extract from Calendula officinalis Lin. Rev Cubana Plant Med [online]. 2006, vol.11, n.3-4. ISSN 1028-4796.

The aim of the present research was to study the effect of three variables in the process of obtention of aqueous extract from flowers of Calendula officinalis Lin., as well their optimization, starting from the maximization of total solids present in the extract, and the recovery values obtained in a lab cylindrical reactor with a non-scale geometry of an industrial reactor. The surface study of the response used a hybrid design, which with 11 experiments attained to analyze three factors at 5 levels, and to give an appropriate response to the need of determining the influence of the process variables and the optimal values for extraction. The drug/diluent ratio proved to be the analyzed variable that influenced the most on the extraction, although all the variables were significant. The optimal parameters for the operation were: a temperature of 100 ºC, a drug/diluent ratio of 1/10, and 2.4 hours of shaking..

Palabras clave : Calendula officinalis; aqueous extract; optimal level.