Resumen

REMIGIO MONTERO, Antonia C et al. Genotoxicity of Indigofera suffruticosa Mill: (añil cimarrón). Rev Cubana Plant Med [online]. 2007, vol.12, n.3. ISSN 1028-4796.

It was accomplished the study of the genotoxic effect of extract  of Indigofera suffruticosa Mill. using the Salmonella/microsoma assay in strains TA 1535, TA 1537, TA 98 and TA 100 was positive in a plate incorporation protocol with concentrations ranging from 50 to 5000 mg/plate (± S9) for the strains TA 1535, TA 1537. The extract of Indigofera suffruticosa Mill. exhibited the significantly increment in the frequency of micronucleated polychromatic erythrocytes in female mice and dose-dependent genotoxicity to mouse bone marrow micronucleus test at the doses of 500, 1000 and 2000 mg/kg assayed.

Palabras clave : Genotoxicity; bone marrow; micronucleus; Indigofera suffruticosa Mill.; Salmonella/microsomas.