Resumo

SANCHEZ PERERA, Luz María; FRAGA CHAVEZ, Ivis; MACEBO DORVENY, Betty  e  MIRANDA, Rafael Lorenzo. Oral acute and sub-acute toxicity of dried aqueous extract from Rhizophora mangle L. in rats. Rev Cubana Plant Med [online]. 2008, vol.13, n.3. ISSN 1028-4796.

Rationale: Rhizophora mangle L. is a highly distributed plant in Cuba, whose effects on gastrointestinal ulcers by several mechanisms of action like cytoprotection, anti-secretion, prostaglandin PGE₂ depletion inhibition and wound healing have been scientifically proved. However, no toxicity studies have been so far conducted Objectives: To determinate oral acute and sub-acute toxicity of dried aqueous extract from R. mangle bark. Methods: The preclinical study of the dried aqueous extract from R. mangle was performed in acute models at a single dose (2000 mg/Kg of body mass) and at daily repeated dose for 14 days at maximum therapeutic dose of 500 mg/Kg of body mass. Male and female Sprague Dawley rats divided into 5-rat groups of each sex per each experimental group. They were systematically observed until 14^th day after the experiment when they were put away. Results: Their body weigh was the characteristic one corresponding to the species. There was no change in the organ weight and no anatomopathological signs with toxic effects were found. Conclusions: Toxic dose of the dried aqueous extract from R. mangle is over 2000 mg/Kg according to a study on single dose. It is not toxic either at repeated doses of maximum therapeutic effect for 14 days; therefore, a wide range of safety is warranted.

Palavras-chave : Rhizophora mangle; oral acute toxicity; oral subacute toxicity.

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