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Revista Cubana de Plantas Medicinales

On-line version ISSN 1028-4796

Abstract

SAUCEDO HERNANDEZ, Yanelis et al. Parthenium hysterophorus L. (escoba amarga) powder stability on the basis of parthenin contents by using high-performance liquid chromatography. Rev Cubana Plant Med [online]. 2009, vol.14, n.3, pp.4-13. ISSN 1028-4796.

INTRODUCTION: Parthenium hysterophorus (escoba amarga) is a well-known antiparasitic plant, but the lack of analytical and technological research studies does not allow following-up the intrinsic stability of the plant solid powder for obtaining a scientifically-proved pharmaceutical form with antiparasitic action. OBJECTIVE: to ascertain the integral stability of the powder from P. hysterophorus foliage under actual storage conditions, taking the parthenin content as a basis. METHODS: the intrinsic P. hysterophorus solid powder stability was determined against external factors such as humidity, temperature and light. RESULTS: the high-performance liquid chromatography is a specific technique to quantify the parthenin contents in P. hysterophorus powder and may be used in the stability studies. It was proved that humidity and light had a negative impact on the chemical stability of the parthenin. CONCLUSIONS: the chemical stability of the solid powder, preserved in amber glass flasks covered with aluminium paper and rubber cap and evaluated according to ICH standards (2005), is not adequate for this substance to be marketed as raw material for dosage form preparations.

Keywords : Parthenium hysterophorus; parthenin; stability.

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