Revista Cubana de Plantas Medicinales
On-line version ISSN 1028-4796
TILLAN CAPO, Juana I.; BELLMA MENENDEZ, Addis; MENENDEZ CASTILLO, Rosa and CARRILLO DOMINGUEZ, Carmen. Antagonist a-adrenergic activity of microencapsulated Cucurbita pepo L. (pumpkin) seed oil. Rev Cubana Plant Med [online]. 2009, vol.14, n.3, pp. 37-44. ISSN 1028-4796.
INTRODUCTION: research works performed on experimental animals administered with microencapsulated Cucurbita pepo L. seed oil, have demonstrated the antiandrogenic and antiinflammatory activity of this product, so it has been recommended for the treatment of benign prostatic hyperplasia. The use of antagonist adrenergic drugs is also recommended. OBJECTIVE: to evaluate the antagonist a-adrenergic activity of the microencapsulated C. pepo seed oil obtained in our center. METHODS: microencapsulated oil concentrations (0.3; 1 y 3 mg/mL) were evaluated on isolated deferent duct in rats against sub-maximum noradrenaline concentrations (10-8 to 10-5 M), with and without 1 mg/mL of the microencapsulated oil. RESULTS: microencapsulated C pepo seed oil was proved to inhibit the contraction induced by the sub-maximum noradrenaline concentration, as well as the cumulative curve of noradrenalin when the oil was present. CONCLUSIONS: microencapsulated C. pepo seed oil has antagonist a-adrenergic effect on tested concentrations in the isolated deferent duct of treated rats
Keywords : oil; Cucurbita pepo; deferent duct; antagonist adrenergic.