Revista Cubana de Plantas Medicinales
versión On-line ISSN 1028-4796
ARTEAGA PEREZ, María Elena et al. Acute toxicity classification of powdered dry fruit of Morinda citrifolia L. (NONI-C)® in Cenp: SPRD rats. Rev Cubana Plant Med [online]. 2009, vol.14, n.4, pp. 0-0. ISSN 1028-4796.
INTRODUCTION: Morinda citrifolia L. has been used in the traditional medicine to reduce the chronic pains, to regulate the blood pressure, to relieve arthritic pains, to eliminate the toxic agents of organism, allergy states and asthma. OBJECTIVES: to classify the dry fruit powder of M. citrifolia NONI-C®according the different acute toxicity kinds. METHODS: we used 6 female rats of Cenp:SPRD subspecies from The National Center for the Production of Laboratory Animals (NCPLA). A 2 g single dose of dry vegetal material/kg of body weight of NONI-C® was administered per os before breakfast. Observation period was of 14 days to monitoring the daily environmental conditions, appearance of toxicity signs, and death, as well as the body weight at 0, 7 and 14 days from assay. RESULTS: animals had a 100 % survival. There were not toxicity signs after assayed substance administration it maximal 2 g/kg dose. In anatomical and pathological evaluation there were neither macroscopic alterations in external surface of animals nor in its cavities, organs and tissues. CONCLUSIONS: accordint to toxicity kinds method, NONI-C® was not classified, acute DL50 is higher than 2 g/kg.
Palabras llave : acute toxic clases; rats; Morinda citrifolia.