Resumo

SAUCEDO HERNANDEZI, Yanelis et al. Specificity of HPLC to assess the chemical stability based on partenine from Parthenium hysterophorus L. powdered dry foliage (escoba amarga). Rev Cubana Plant Med [online]. 2010, vol.15, n.1. ISSN 1028-4796.

INTRODUCTION: it is required a specific analysis technique allowing the follow-up to stability study intrinsic of Parthenium hysterophorus L. (escoba amarga) powdered dry foliage to achieve in a pharmaceutical way a antiparasitic usefulness with the quality, safety and effectiveness demanded requirements. OBJECTIVE: to demonstrate the specificity of analytical technique of high-performance liquid chromatography for quantization of partenine in the powder of P. hysterophorus for its application in stability studies. METHODS: high performance liquid chromatography was applied to P. hysterophorus degraded samples under degradation conditions in an oxidative, basic and acid medium.The analysis technique specificity was assessed to detect the interest component without interferences of its degradation products and its possible usefulness in studies on solid stability in the plant powder. RESULTS: high-performance liquid chromatography to quantify the presence of partenine in the P. hysterophorus powder was specific in established work conditions and may be used in solid stability studies of plant powder. CONCLUSIONS: the high-performance proposed is specific and it is recommended in solid stability studies of solids in plant powder.

Palavras-chave : Parthenium hysterophorus; partenine; high-performance liquid chromatography.

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