Resumo

FRANCO OSPINA, Luis Alberto et al. Antiinflammatory, antioxidant and antibacterial activity of two species of Tabebuia genus. Rev Cubana Plant Med [online]. 2013, vol.18, n.1, pp. 34-46. ISSN 1028-4796.

Introduction: Tabebuia rosea (Bertol.) A. DC. and Tabebuia ochracea (Cham.) Standl., belonging to the Bignoniaceae family, are widely used in folk medicine because of their antiinflammatory and antibacterial potentialities, all of which has prompted the chemical and biological study of these species. Objectives: to evaluate the antiinflammatory, antioxidant and antibacterial activity of the total ethanolic extracts and fractions obtained from the inner bark of Tabebuia rosea and Tabebuia ochracea by using ether, dichloromethane, ethyl acetate and ethanol. Methods: plant material was extracted through maceration with ethanol and fractionated through liquid-liquid partition method. The evaluation of antiinflammatory action used the 12-O-tetradecanoylphorbol-13-acetate induced ear edema in mice, whereas the antioxidant and antibacterial activities were determined in vitro, using the 2,22 -diphenyl-1-picrylhydrazyl radical scavenging method and agar well diffusion method, respectively. Results: ethanol extracts from Tabebuia rosea and Tabebuia ochracea inner bark, as well as some of their fractions showed significant antiinflammatory and antioxidant activity, being generally Tabebuia rosea more active as antiinflammatory. Regarding the antioxidant activity Tabebuia ochracea proved to be more potent. Both Tabebuia species revealed significant antibacterial activity against Staphylococcus aureus ATCC 25923. Conclusions: it was proven that total extracts and fractions obtained from Tabebuia rosea and Tabebuia ochracea had antiinflammatory, free radical DPPH scavenging capacity, and antibacterial activity. This is the first report which validates the popular use of these species as antiinflammatory and antibacterial agents in the north coast of Colombia.

Palavras-chave : Tabebuia; antiinflammatory agents; antioxidants; anti-bacterial agents.

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