Resumo

GARCIA HERNANDEZ, Ana Ibis et al. Reduction of the intestinal transit and lack of preclinical acute toxicology of decoction from Phania matricarioides (Spreng.) Griseb fresh aerial parts. Rev Cubana Plant Med [online]. 2013, vol.18, n.1, pp.71-83. ISSN 1028-4796.

Introduction: Phania matricarioides (Spreng.) Griseb (chamomile) fresh aerial part decoction is traditionally used in Cuba to treat digestive disorders as upset stomach and simple acute diarrheas. However, there were no previous preclinical validation studies on the antidiarrheal effect and safety of this species. Objectives: to evaluate the action of decoction from Phania matricarioides fresh aerial parts on the intestinal transit and the oral and topical acute toxicology in preclinical models. Methods: the fresh aerial parts of this plant were harvested and decoction was obtained (30 and 50 %). The experimental model of intestinal transit in mice, with 30 % decoction being administrated once at doses of 1.0, 5.0 and 10.0 g of vegetal material/kg of bodyweight for one day, and at doses of 1.0 and 5.0 g/kg for 4 days, was applied. The oral and topical toxicological study (50 % decoction) was conducted in the models acute-toxic and acute dermal toxic classes in rats at a dose of 2000 mg/kg of bodyweight and primary dermal irritability in rabbits. Results: the decoction administered for one day did not significantly change the intestinal transit, but the administration for 4 days did significantly change, depending on dose, the intestinal transit (5.0 g/kg). There was no death in the study, there were neither signs of toxicity nor macroscopic lesions in the rats' organs, whereas the weight gain behaved as expected. The index of primary irritation was null. Conclusions: the results allow validating the antidiarrheal effect of Phania matricarioides fresh aerial parts decoction on digestive disorders and it is not toxic.

Palavras-chave : Phania matricarioides (Spreng.) Griseb; chamomile; diarrhea; toxicology; antidiarrheal.

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