Resumo

MORENO MENDOZA, Miguel Ángel; PARADA PALACIOS, Elvert Antonio; MEJIA VALENCIA, José Guillermo  e  ESPINOZA MADRID, Paul Augusto. Subchronic toxicology of Chenopodium ambrosioides (epazote) infusion orally administered to NIH mice. Rev Cubana Plant Med [online]. 2013, vol.18, n.1, pp.157-170. ISSN 1028-4796.

Introduction: medicinal plants represent a valuable therapeutic alternative and their scientific validation is a must. Objectives: to determine the possible toxic effects produced by the infusion of Chenopodium ambrosioides L. (Chenopodiaceae) on the used biological model. Methods: to determine the subchronic toxicity of the infusion, NIH Swiss albino mice of both sexes were used, to which infusions from the tested species, at concentrations of 32, 64, and 134 mg/mL , were orally administered for 90 days. At the same time, daily clinical observations were performed in order to identify any toxic post-dose administration. Afterwards, they were sacrificed for conduction of hematological tests (hematocrit, hemoglobin, red blood cells, white cells, neutrophils and lymphocytes) and biochemical (alanine aminotransferase and creatinine) and macroscopic and histological studies of the internal organs (kidney, liver, lung and intestine.). Results: the infusion of Chenopodium ambrosioides at the tested doses caused neither decisively significant effects on the toxicological parameters, body weight, hematology and blood chemistry nor pathological changes on organs and tissues. Conclusions: the infusion of Chenopodium ambrosioides under our experimental conditions showed no toxic activity.

Palavras-chave : Chenopodium ambrosioides; repeat dose; subchronic oral toxicity.

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