Abstract

NAPOLES MENDEZ, Danilo  and  ALVAREZ GUERRA, Eloy. Chromatographic determination of misoprostol at a low dose in neonatal plasm and mother colostrum. MEDISAN [online]. 2011, vol.15, n.5, pp.580-590. ISSN 1029-3019.

A chromatography study was conducted with the aim of a qualitative analysis to define a range of safety, demonstrate the presence or absence of misoprostol in neonatal blood or mother colostrum when used at low doses (25 micrograms) vaginally in patients with dystocia in latent stage of labor, as well as to determine the presence of complications in the newborn. The samples were analyzed in 2 times between 2008 and 2009, after coordination of "Mariana Grajales Coello" Obstetrics and Gynecology Hospital in Santiago de Cuba with the Center for Medical Biophysics of the Oriente University and the National Center of Toxicology in Havana city, although the research was part of a phase III clinical trial, where misoprostol was used in 327 pregnant women. For chromatography 50 samples of neonatal plasm and 50 of mother colostum were chosen from patients that gave birth in the first 6 hours after the last dose of the medication, when supposedly there is activity in plasma. Newborns were observed clinically for 72 hours, at which time laboratory tests were indicated to specify potential complications, but these did not occur, nor was it possible to quantify signals on the retention times expected for derivatives and the active ingredient of misoprostol. It was concluded that in the conditions of administration established in our cases the chromatographic data obtained show that the dose used is safe for the baby.

Keywords : pregnant woman; newborn; neonatal plasm; mother colostrum; chromatography; misoprostol.

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