Abstract

GUERRA GONZALEZ, Alicia et al. Genome-environment Interaction in the ocurrence of type 2 diabetes mellitus. MEDISAN [online]. 2012, vol.16, n.2, pp.196-204. ISSN 1029-3019.

An analytic and observational study of cases and controls was carried out in the health area belonging to "Josué País García" Polyclinic in Santiago de Cuba, during the trimester from September to November, 2010, with the purpose of determining the interaction genome-environment in the ocurrence of type 2 diabetes mellitus. The study group was constituted by 80 patients with this disease, selected by means of simple random sampling; and the control group included 160 people without it. The X² test, with 0,05 significance level was applied, and the odds ratio was calculated to evaluate the association magnitude between the variables. The most significant risk factors were obesity and sedentary lifestyle, as well as the existence of the disorder in first degree relatives from patients of the case group. Likewise, the interaction of a predisposing genome with the adverse environmental factors was evidenced, for what it is recommended to work in the primary health care on the base of the well-known risk agents which may influence in the beginning of this clinical entity.

Keywords : type 2 diabetes mellitus; interaction genome-environment; genetic and environmental factors; family aggregation; primary health care.

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